منابع مشابه
A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation
Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-ray crystal structure of human IKK2 (hIKK2) in its catalytically active conformation. The hIKK2 domain architecture closely resembles that of Xenopus IK...
متن کاملConsequent Protein Oligomerization and Primase Activation
243 words 23 Text 5,314 words 24 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.01690-10 JVI Accepts, published online ahead of print on 10 November 2010 on O cber 0, 2017 by gest http/jvi.asm .rg/ D ow nladed fom Herpes simplex virus type 1 helicase/primase Chen et al.
متن کاملAutoproteolytic activation of pro-caspases by oligomerization.
Initiation of apopotosis requires the conversion of procaspases to mature caspases. Here we show that oligomerization of pro-caspases is sufficient to induce proteolytic generation of mature caspase subunits and activation of their cell death activity. Deletion of the protein interaction motif DED from pro-caspase-8 greatly suppresses its apoptotic activity. Cell death activity can be restored ...
متن کاملTip-induced C-H activation and oligomerization of thienoanthracenes.
The tip of a scanning tunneling microscope (STM) can be used to dehydrogenate freely-diffusing tetrathienoanthracene (TTA) molecules on Cu(111), trapping the molecules into metal-coordinated oligomeric structures. The process proceeds at bias voltages above ~3 V and produces organometallic structures identical to those resulting from the thermally-activated cross-coupling of a halogenated analo...
متن کاملFSHR Gene Polymorphisms Causes Male Infertility
Prior studies suggested sperm with damaged DNA permits fertilization but may lead to failure of embryo implantation following blastocyst formation. Quantitative correlations between DNA damage and risk of implantation failure have, however, so far not been performed. The aim of this study was to investigate two FSHR gene polymorphisms G919A (Ala307Thr) and A2039G (Asn680Ser) in Eastern Ukrainia...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2018
ISSN: 1664-2392
DOI: 10.3389/fendo.2018.00760